Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute (SERI), Singapore; Duke University School of Medicine, Durham, NC, USA.
Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute (SERI), Singapore.
Free Radic Biol Med. 2018 Oct;126:210-220. doi: 10.1016/j.freeradbiomed.2018.08.017. Epub 2018 Aug 16.
Peroxiredoxin 6 (Prdx6) is the only mammalian 1-Cys member of the Prdx family, a group of enzymes which share the ability to reduce peroxides. In addition to its peroxidase function, Prdx6 also demonstrates phospholipase A and lysophosphatidylcholine acyl transferase (LPCAT) activities. These enzymatic activities play an important role in regenerating oxidized membrane phospholipids and maintaining an appropriate balance of intracellular reactive oxygen species. Development of clinical pathologies, including those within the eye, have been linked to dysregulation of Prdx6 function. Interplay between external stressors like exposure to UV light, transforming growth factor β (TGF-β), and hyperglycemia in conjunction with diminished Prdx6 levels and loss of redox balance is associated with cellular changes in a variety of ophthalmic pathologies including cataracts, glaucoma, and retinal degeneration. Many of these cellular abnormalities can be rescued through supplementation with exogenous Prdx6. Additionally, corneal endothelial cells have been found to express high levels of Prdx6 in the plasma membrane. These findings highlight the importance of Prdx6 as an essential regulator of oxidative stress in the eye.
过氧化物酶 6（Prdx6）是 Prdx 家族中唯一的哺乳动物 1-Cys 成员，该家族的酶具有还原过氧化物的能力。除了过氧化物酶功能外，Prdx6 还具有磷脂酶 A 和溶血磷脂酰胆碱酰基转移酶（LPCAT）活性。这些酶活性在再生氧化的膜磷脂和维持适当的细胞内活性氧平衡方面发挥着重要作用。包括眼部疾病在内的临床病理学的发展与 Prdx6 功能的失调有关。与 Prdx6 水平降低和氧化还原平衡丧失相关的外部应激因子（如暴露于紫外线下、转化生长因子β（TGF-β）和高血糖）之间的相互作用与各种眼科病理学中的细胞变化有关，包括白内障、青光眼和视网膜变性。通过补充外源性 Prdx6 可以挽救许多这些细胞异常。此外，还发现角膜内皮细胞在质膜中表达高水平的 Prdx6。这些发现强调了 Prdx6 作为眼睛中氧化应激的重要调节剂的重要性。
