腰果（Anacardium occidentale L.）辐照提取物对耐多药金黄色葡萄球菌菌株的抗菌活性
Antibacterial activity of irradiated extracts of Anacardium occidentale L. on multiresistant strains of Staphylococcus aureus.
作者信息
Dos Santos Gustavo Henrique Farias, Amaral Ademir, da Silva Edvane Borges
机构信息
Grupo de Radioproteção e Radioecologia-GERAR, Universidade Federal de Pernambuco/Departamento de Energia Nuclear, Av. Prof. Luiz Freire, 1000. Cidade Universitária, Recife CEP 50740-540, Brazil.
Grupo de Radioproteção e Radioecologia-GERAR, Universidade Federal de Pernambuco/Departamento de Energia Nuclear, Av. Prof. Luiz Freire, 1000. Cidade Universitária, Recife CEP 50740-540, Brazil; Centro Acadêmico de Vitória, Rua do Alto do Reservatório, s/n - Bela Vista, Vitória de Santo Antão CEP 50670-901, PE, Brazil.
出版信息
Appl Radiat Isot. 2018 Oct;140:327-332. doi: 10.1016/j.apradiso.2018.07.035. Epub 2018 Aug 1.
This study evaluated the antibacterial activity of crude and fractionated leaf extracts of Anacardium occidentale, after receiving 10 kGy from Co, against multiresistant strains of Staphylococcus aureus in vitro. Minimum Inhibitory Concentrations-MIC and Minimum Bacteriostatic Concentrations-MBC were respectively assessed by serial microdilution technique in multiwall plates and Petri dishes, against standard strains and clinical isolates of multiresistant S. aureus. The results pointed out a significantly increase of the antibacterial activity of the such extracts after irradiation, emphasizing the role of gamma radiation on leaf extracts of A. occidentale to improve bioactive substances, offering new raw material for antibacterial drugs.
本研究评估了腰果叶粗提物和分级提取物在接受来自钴的10千戈瑞辐射后，对耐多药金黄色葡萄球菌菌株的体外抗菌活性。通过在多壁板和培养皿中采用系列微量稀释技术，分别针对耐多药金黄色葡萄球菌的标准菌株和临床分离株评估了最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。结果指出，辐照后此类提取物的抗菌活性显著增强，强调了γ辐射对腰果叶提取物改善生物活性物质的作用，为抗菌药物提供了新的原材料。
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