Guler Gulen, Kutuk Meryem Ozlem, Kara Halil
Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Elazig, Turkey.
Department of Child and Adolescent Psychiatry, Baskent University Medical Faculty, Adana, Turkey.
Clin Psychopharmacol Neurosci. 2018 Aug 31;16(3):343-345. doi: 10.9758/cpn.2018.16.3.343.
Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Additionally, this case showed that the patient recovered from the amenorrhea with replacement of aripiprazole with quetiapine.
闭经、月经过少、溢乳、男子女性型乳房、不孕和性功能障碍可能是高催乳素血症的结果。高催乳素血症是抗精神病药物治疗的主要副作用之一，但阿立哌唑是一种多巴胺稳定剂类抗精神病药物，可用于改善高催乳素血症。在本报告中，描述了一名青少年患者在正在进行的氟西汀治疗重度抑郁症方案中添加极低剂量阿立哌唑后出现闭经。此外，该病例表明，用喹硫平替代阿立哌唑后，患者的闭经症状得以恢复。
