Dattagupta Aditi, Immaneni Sathyamurthy
Department of Cardiology, Sakra World Hospital, Bangalore, India; Cardiology, Apollo Main Hospital, Chennai, India.
Department of Cardiology, Apollo Main Hospital, Chennai 600006, India.
Indian Heart J. 2018 Jul;70 Suppl 1(Suppl 1):S96-S101. doi: 10.1016/j.ihj.2018.03.001. Epub 2018 Mar 3.
Cardiovascular diseases are leading cause of mortality and morbidity, and are responsible for 1 out of every 6 deaths in the United States. Cardiac remodeling is an important determinant of long term outcomes and occurrence of heart failure (HF). Many times one requires additional tools like biomarkers to identify high risk individuals, to diagnose disease conditions accurately and to effectively prognosticate the patients. ST2 is a member of the interleukin 1 receptor family and exists in two forms, a trans-membrane receptor (ST2L) as well as a soluble decoy receptor (sST2). The ligand of ST2 is Interleukin-33 (IL-33), which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues..
心血管疾病是导致死亡和发病的主要原因，在美国每6例死亡中就有1例与之相关。心脏重塑是长期预后和心力衰竭（HF）发生的重要决定因素。很多时候，人们需要像生物标志物这样的额外工具来识别高危个体、准确诊断疾病状况并有效地预测患者的预后。ST2是白细胞介素1受体家族的成员，以两种形式存在，一种是跨膜受体（ST2L），另一种是可溶性诱饵受体（sST2）。ST2的配体是白细胞介素-33（IL-33），它参与减少机械应变组织中的纤维化和肥大。
