Heusinkveld Lauren E, Hacker Mallory L, Turchan Maxim, Davis Thomas L, Charles David
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Front Neurol. 2018 Aug 3;9:628. doi: 10.3389/fneur.2018.00628. eCollection 2018.
Tremor is one of the most visible features of Parkinson's disease (PD), and the majority of PD patients experience tremor during the course of the disease. However, the distress caused by this cardinal motor feature for patients early in the course of their PD is commonly underappreciated. People living with early stage PD often experience intense embarrassment and difficulties due to their tremor that limit social interactions, and tremor frequently interferes with the ability to perform activities of daily living and simple tasks at home and work. Although tremor is primarily managed with medications, both tremor response and satisfaction with medical therapy are highly variable. This review offers an overview of reports of the patient experience of tremor in early stage PD and current management options for this cardinal motor feature.
震颤是帕金森病(PD)最明显的特征之一,大多数PD患者在疾病过程中会出现震颤。然而,这种主要运动特征在PD病程早期给患者带来的困扰通常未得到充分认识。早期PD患者常因震颤而感到极度尴尬和困难,这限制了他们的社交互动,而且震颤经常干扰他们在家中和工作中进行日常生活活动和简单任务的能力。尽管震颤主要通过药物治疗,但震颤反应和对药物治疗的满意度差异很大。本综述概述了早期PD患者震颤体验的报告以及针对这一主要运动特征的当前管理方案。