Bron Peter A, Kleerebezem Michiel
NIZO Food Research BV, Ede, Netherlands.
BE-Basic Foundation, Delft, Netherlands.
Front Microbiol. 2018 Aug 3;9:1821. doi: 10.3389/fmicb.2018.01821. eCollection 2018.
Food-grade lactic acid bacteria (LAB) are considered suitable vehicles for the production and/or delivery of health promoting or therapeutic, bioactive molecules. The molecules considered for health-beneficial use include the endogenous effector molecules produced by probiotics (mostly lactobacilli), as well as heterologous bioactives that can be produced in LAB by genetic engineering (mostly using lactococci). Both strategies aim to deliver appropriate dosages of specific bioactive molecules to the site of action. This review uses specific examples of both strategies to illustrate the different avenues of research involved in these applications as well as their translation to human health-promoting applications. These examples pinpoint that despite the promising perspectives of these approaches, the evidence for their effective applications in human populations is lagging behind.
食品级乳酸菌（LAB）被认为是生产和/或递送促进健康或治疗性生物活性分子的合适载体。用于有益健康用途的分子包括益生菌（主要是乳酸杆菌）产生的内源性效应分子，以及可通过基因工程在乳酸菌中产生的异源生物活性物质（主要使用乳酸球菌）。这两种策略的目的都是将适当剂量的特定生物活性分子递送至作用部位。本综述使用这两种策略的具体例子来说明这些应用所涉及的不同研究途径，以及它们向促进人类健康应用的转化。这些例子指出，尽管这些方法前景广阔，但它们在人群中有效应用的证据仍滞后。
