来自青藏高原真菌的化学多样性以及…… （原文不完整，翻译至此）
Chemical diversity from the Tibetan Plateau fungi and .
作者信息
Liu Zhi-Guo, Bao Li, Liu Hong-Wei, Ren Jin-Wei, Wang Wen-Zhao, Wang Long, Li Wei, Yin Wen-Bing
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Mycology. 2017 Jun 12;9(1):10-19. doi: 10.1080/21501203.2017.1331937. eCollection 2018.
Two new secondary metabolites, kongiilines A and B (), and two asperphenamate derivatives, asperphenamates B and C (-), together with 16 known compounds (--), were isolated from Tibetan Plateau fungi and . This is the first report on asperphenamates B and C as naturally occurring compounds, and that aspterric acid is isolated from for the first time. Their structures were elucidated by different spectroscopic techniques including high-resolution electrospray ionisation mass spectrum, 1D nuclear magnetic resonance (NMR), and 2D NMR as well as electronic circular dichroism. Compounds and exhibited cytotoxicity activities against human colon carcinoma HCT116 cell line with IC values of 88.16, 77.68, and 36.92 μM, respectively. Fungi from Tibetan Plateau represent important and rich resources for the investigation of new chemicals.
从青藏高原真菌和中分离出两种新的次生代谢产物，孔吉啉A和B（），以及两种曲霉芬酸衍生物，曲霉芬酸B和C（-），还有16种已知化合物（--）。这是关于曲霉芬酸B和C作为天然存在化合物的首次报道，也是首次从曲霉中分离出曲霉酸。通过包括高分辨率电喷雾电离质谱、一维核磁共振（NMR）、二维NMR以及电子圆二色性在内的不同光谱技术对它们的结构进行了阐明。化合物和对人结肠癌HCT116细胞系表现出细胞毒性活性，IC值分别为88.16、77.68和36.92μM。青藏高原的真菌是研究新化学物质的重要且丰富的资源。
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