铜催化的立体选择性脱溴硼化脂肪族 1,1-二溴-1-烯烃与双(频哪醇)二硼。
Copper(i)-catalysed stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes with bis(pinacolato)diboron.
机构信息
Division of Applied Chemistry and Frontier Chemistry Center, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
出版信息
Org Biomol Chem. 2018 Aug 29;16(34):6187-6190. doi: 10.1039/c8ob01778f.
A stereoselective debromoborylation of aliphatic 1,1-dibromo-1-alkenes to prepare (Z)-1-bromo-1-alkenylboronate esters using copper(i) catalysts was developed. The debromoborylation of various aliphatic 1,1-dibromo-1-alkenes in the presence of a copper(i) catalyst and bis(pinacolato)diboron proceeded smoothly to produce (Z)-1-bromo-1-alkenylboronate esters in good yields with only Z geometry.
发展了一种使用铜（I）催化剂对脂肪族 1,1-二溴-1-烯烃进行立体选择性去溴硼化反应，以制备（Z）-1-溴-1-烯基硼酸酯。在铜（I）催化剂和双（频哪醇合）二硼的存在下，各种脂肪族 1,1-二溴-1-烯烃的去溴硼化反应顺利进行，以良好的收率得到了仅具有 Z 几何构型的（Z）-1-溴-1-烯基硼酸酯。
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