Negosanti Francesca, Tengattini Vera, Gurioli Carlotta, Neri Iria
Centro Dermatologico, Bologna, Italy.
Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.
J Cosmet Dermatol. 2018 Oct;17(5):762-765. doi: 10.1111/jocd.12725. Epub 2018 Aug 19.
Tuberous sclerosis is an autosomal dominant genodermatosis characterized by nonmalignant hamartomas in multiple organs. Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement. Facial disfigurement negatively affects the quality of life of patients and their families, often leading to negative psychosocial outcomes. Nowadays there are no treatment guidelines for facial angiofibromas but due to the progressive nature of facial angiofibromas a safe technique offering good results is needed.
We report the case of a 40-year-old female affected by tuberous sclerosis, whose facial angiofibromas were satisfactorily treated by rapamycin 0.05% ointment, and a combined laser therapy.
结节性硬化症是一种常染色体显性遗传性皮肤病，其特征为多个器官出现非恶性错构瘤。面部血管纤维瘤最常见于面部，有导致毁容的可能。面部毁容会对患者及其家人的生活质量产生负面影响，常导致负面的心理社会后果。目前尚无针对面部血管纤维瘤的治疗指南，但鉴于面部血管纤维瘤的渐进性，需要一种能产生良好效果的安全技术。
我们报告了一名40岁患结节性硬化症女性的病例，其面部血管纤维瘤通过0.05%雷帕霉素软膏及联合激光治疗得到了满意的疗效。
