青少年饮酒与丹麦队列中多发性硬化症风险降低相关。

Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort.

机构信息

Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

The Danish Multiple Sclerosis Registry, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

出版信息

Mult Scler. 2019 Oct;25(12):1572-1579. doi: 10.1177/1352458518795418. Epub 2018 Aug 20.

DOI:10.1177/1352458518795418

PMID:30124094

Abstract

BACKGROUND AND OBJECTIVE

Due to the possible existence of a vulnerable period of multiple sclerosis (MS) susceptibility in adolescence and because Danish teenagers have a high alcohol consumption, we investigated the association between alcohol consumption at ages 15-19 and the risk of developing MS.

METHODS

A total of 1717 patients with MS and 4685 healthy blood donors filled in a comprehensive environmental and lifestyle questionnaire. Data were analysed by logistic regression models and adjusted for selected confounders.

RESULTS

We found an inverse association between alcohol consumption in adolescence and risk of developing MS in both women ( < 0.001) and men ( = 0.012). Women with low alcohol consumption had an odds ratio (OR) of 0.56 (95% confidence interval (CI): 0.47-0.66) compared with non-drinking women. The ORs were similar for women with moderate (OR = 0.49, 95% CI: 0.38-0.62) and high consumption (OR = 0.57, 95% CI: 0.38-0.84). Men with low alcohol consumption had an OR of 0.69 (95% CI: 0.53-0.89) compared with non-drinking men but no decreased risk was found for men with moderate and high consumption.

CONCLUSION

Alcohol consumption in adolescence was associated with lower risk of developing MS among both sexes.

摘要

背景与目的

由于多发性硬化症（MS）易感性在青春期可能存在脆弱期，且丹麦青少年的酒精摄入量较高，我们研究了 15-19 岁时的饮酒与 MS 发病风险之间的关系。

方法

共有 1717 名 MS 患者和 4685 名健康献血者填写了一份全面的环境和生活方式问卷。使用逻辑回归模型进行数据分析，并对选定的混杂因素进行了调整。

结果

我们发现，在女性（ < 0.001）和男性（ = 0.012）中，青少年期饮酒与 MS 发病风险呈负相关。与不饮酒的女性相比，低饮酒量的女性的比值比（OR）为 0.56（95%置信区间（CI）：0.47-0.66）。中度（OR = 0.49，95% CI：0.38-0.62）和高（OR = 0.57，95% CI：0.38-0.84）饮酒量的女性的 OR 相似。与不饮酒的男性相比，低饮酒量的男性的 OR 为 0.69（95% CI：0.53-0.89），但中度和高饮酒量的男性并未发现风险降低。