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惰性气体与蛋白质和脂质的麻醉分子相互作用及其影响:综述

Anesthetic Molecule Interaction of Noble Gases with Proteins and Lipids and their Effect: A Review.

作者信息

Kundu Shyamal Kumar, Chakraborty Chiranjib, Yagihara Shin, Teoh Seong Lin, Das Srijit

机构信息

Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, India.

Department of Physics, Tokai University, Hiratsuka-Shi, Kanagawa 259-1292, Japan.

出版信息

Curr Drug Deliv. 2018;15(10):1381-1392. doi: 10.2174/1567201815666180820101255.

Abstract

Surgical operations are impossible without administering proper analgesia. Advancement in the field of anesthesia has invariably resulted in the accomplishment of all surgical processes without any inconvenience. Admittedly, the use of noble gas is on the decline. The noble gases may not interact chemically with any other substance under normal temperature and pressure but they may interact with proteins and lipids. Different anesthetic molecules may stimulate either proteins or lipids in membrane. There is a connection between the anesthetic molecules and the hydrophobic region of the membrane. In the present review, we attempt to highlight the interaction between the anesthetic molecule with proteins and lipids and their effects. We sketched few noble gases and some other existing molecules such as halothane and alcohol which interacted with proteins and lipids.

摘要

没有适当的镇痛措施,外科手术就无法进行。麻醉领域的进步始终使得所有外科手术得以顺利完成而不会带来任何不便。诚然,惰性气体的使用正在减少。惰性气体在常温常压下可能不会与任何其他物质发生化学反应,但它们可能与蛋白质和脂质发生相互作用。不同的麻醉分子可能刺激膜中的蛋白质或脂质。麻醉分子与膜的疏水区域之间存在联系。在本综述中,我们试图突出麻醉分子与蛋白质和脂质之间的相互作用及其影响。我们简述了一些与蛋白质和脂质相互作用的惰性气体以及其他一些现有的分子,如氟烷和酒精。

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