Li Weiwei, Bai Li, Fu Ping, Han Haihong, Liu Jikai, Guo Yunchang
Division of Foodborne Disease Surveillance, China National Center for Food Safety Risk Assessment , Beijing, China .
Foodborne Pathog Dis. 2018 Aug;15(8):459-466. doi: 10.1089/fpd.2017.2409.
Listeria monocytogenes, a ubiquitous bacterium in nature, can lead to human listeriosis through food consumption. Listeriosis is a rare, preventable, and treatable foodborne disease but can cause hospitalizations and fatalities. We reviewed the literature published in China to better understand the prevalence of L. monocytogenes in food products, incidence of human listeriosis, and characteristics of L. monocytogenes strains in China. The average prevalence of L. monocytogenes in Chinese food products in 28 provinces was 4.42%, with the highest prevalence of 8.91% in meat-poultry products, followed by aquatic animals, Chinese salad and salad, rice and flour products, and so on. Two hundred fifty-three invasive listeriosis cases were reported from 2011 to 2016 in 19 provinces, and the overall case-fatality rate was 25.7% with no deaths reported of pregnant women and children. L. monocytogenes strains were generally susceptible to most antibiotics, with ampicillin and penicillin G still effective in treatment. The predominant sequence types (STs) in food were ST9 and ST8, while clinically ST87 was most common ST in China. The national human listeriosis pilot surveillance started in 2013, and a total of 133 listeriosis cases have been collected until now. On the basis of the surveillance program, further research should be conducted to uncover the reason for the prevalence and pathogenic mechanism of the highly epidemiological hypervirulent ST87 strains in China.
单核细胞增生李斯特菌是一种自然界中普遍存在的细菌，可通过食用食物导致人类感染李斯特菌病。李斯特菌病是一种罕见的、可预防和可治疗的食源性疾病，但可导致住院和死亡。我们回顾了中国发表的文献，以更好地了解中国食品中单核细胞增生李斯特菌的流行情况、人类李斯特菌病的发病率以及中国单核细胞增生李斯特菌菌株的特征。28个省份中国食品中单核细胞增生李斯特菌的平均流行率为4.42%，其中肉禽产品中流行率最高，为8.91%，其次是水生动物、中式沙拉和沙拉、米面制品等。2011年至2016年，19个省份报告了253例侵袭性李斯特菌病病例，总体病死率为25.7%，孕妇和儿童无死亡报告。单核细胞增生李斯特菌菌株通常对大多数抗生素敏感，氨苄西林和青霉素G在治疗中仍然有效。食品中主要的序列类型（STs）为ST9和ST8，而临床上ST87是中国最常见的ST。国家人类李斯特菌病试点监测于2013年开始，截至目前共收集到133例李斯特菌病病例。在监测计划的基础上，应进一步开展研究，以揭示中国高流行率的高毒力ST87菌株的流行原因和致病机制。
