Division of General Pediatrics, Department of Pediatrics, Cohen Children's Medical Center.
Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Cohen Children's Medical Center, New Hyde Park.
Curr Opin Pediatr. 2018 Dec;30(6):864-873. doi: 10.1097/MOP.0000000000000681.
Over 80% of children diagnosed with cancer are now cured. The burgeoning population of survivors of childhood cancer experiences high rates of morbidity and mortality due to 'late-effects' of treatment. These can be defined as any consequence of treatment that persists beyond or develops after the completion of cancer therapy. Awareness of late-effects is critically important for pediatricians and adult providers alike, as late-effects impact children in proximity to cancer treatment, as well as adults many decades removed. This review presents the importance of lifelong follow-up care for survivors, highlights existing screening guidelines, and reviews various models of survivor care.
National and international guidelines have been developed to standardize screening for survivors, and multiple models of survivorship care exist. The optimal model likely depends on individual factors, including the survivor's needs and preferences, as well as local resources. Key strategies for the successful care of survivors include accurate risk-stratification for specific late-effects, individualized screening plans, education of survivors and professionals, clear communication between providers, and well coordinated transition of care across services.
Early identification and management of late-effects are important for survivors of childhood cancer. Providers should be familiar with the risks for specific late-effects and have access to screening guidelines. The strengths and weaknesses of care models, along with individual circumstances, should be considered in designing the optimal approach to care for each survivor.
目前,超过 80%的癌症患儿得以治愈。儿童癌症幸存者人数不断增加,他们因治疗的“晚期效应”而出现高发病率和死亡率。这些晚期效应可以定义为癌症治疗完成后持续存在或发展的任何治疗后果。儿科医生和成人医生都必须高度重视这些晚期效应,因为它们不仅会影响临近癌症治疗的儿童,还会影响几十年后已经成年的幸存者。本文介绍了为幸存者提供终身随访护理的重要性,强调了现有的筛查指南,并回顾了各种生存者护理模式。
已经制定了国家和国际指南来规范幸存者的筛查,并且存在多种生存者护理模式。最佳模式可能取决于个体因素,包括幸存者的需求和偏好,以及当地资源。成功护理幸存者的关键策略包括对特定晚期效应进行准确的风险分层、制定个性化的筛查计划、对幸存者和专业人员进行教育、提供者之间的清晰沟通,以及在服务之间顺利过渡护理。
早期识别和管理晚期效应对儿童癌症幸存者很重要。医疗服务提供者应熟悉特定晚期效应的风险,并能获得筛查指南。在为每个幸存者设计最佳护理方法时,应考虑护理模式的优缺点以及个人情况。