Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Austria; Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research at MIT, Langer Lab, 77 Massachusetts Ave, Cambridge, MA 02139, USA.
Brno University of Technology, Faculty of Chemistry, Centre for Materials Research, Purkyňova 118, 612 00 Brno, Czech Republic.
Int J Pharm. 2018 Oct 25;550(1-2):309-315. doi: 10.1016/j.ijpharm.2018.08.032. Epub 2018 Aug 17.
This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.
本研究采用溶剂蒸发法制备包含知名聚合物的薄膜，以研究其用于口腔贴合的潜力。使用不同的聚合物（如乙基纤维素、羟乙基纤维素、羟丙基甲基纤维素以及羧甲基纤维素）来制造黏膜粘附性薄膜。对口腔薄膜的黏膜粘附性、溶胀和物理化学性质进行了评估。此外，还对口腔猪黏膜进行了流变学测量和粘附研究。此外，还加入了保湿剂尿囊素并测定了跨黏膜水损失。结果表明，物理化学性质、口腔黏附性和溶胀性能取决于聚合物的组成。研究结果表明，含有尿囊素的薄膜适用于口腔应用。总之，黏附性薄膜是口腔内各种疾病治疗的合适且有前景的配方。
