Hosny Khaled M, Alkhalidi Hala M, Alharbi Waleed S, Md Shadab, Sindi Amal M, Ali Sarah A, Bakhaidar Rana B, Almehmady Alshaimaa M, Alfayez Eman, Kurakula Mallesh
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2021 Dec 27;14(1):92. doi: 10.3390/polym14010092.
Natural polymers are revolutionizing current pharmaceutical dosage forms design as excipient and gained huge importance because of significant influence in formulation development and drug delivery. Oral health refers to the health of the teeth, gums, and the entire oral-facial system that allows us to smile, speak, and chew. Since years, biopolymers stand out due to their biocompatibility, biodegradability, low toxicity, and stability. Polysaccharides such as cellulose and their derivatives possess properties like novel mechanical robustness and hydrophilicity that can be easily fabricated into controlled-release dosage forms. Cellulose attracts the dosage design attention because of constant drug release rate from the precursor nanoparticles. This review discusses the origin, extraction, preparation of cellulose derivatives and their use in formulation development of nanoparticles having multidisciplinary applications as pharmaceutical excipient and in drug delivery, as bacterial and plant cellulose have great potential for application in the biomedical area, including dentistry, protein and peptide delivery, colorectal cancer treatment, and in 3D printable dosage forms.
天然聚合物作为辅料正在彻底改变当前药物剂型的设计，并且由于其在制剂开发和药物递送中具有重大影响而变得极为重要。口腔健康是指牙齿、牙龈以及整个口腔面部系统的健康，这些部位使我们能够微笑、说话和咀嚼。多年来，生物聚合物因其生物相容性、生物可降解性、低毒性和稳定性而脱颖而出。诸如纤维素及其衍生物之类的多糖具有新颖的机械强度和亲水性等特性，能够很容易地制成控释剂型。纤维素因其前体纳米颗粒具有恒定的药物释放速率而在剂型设计中备受关注。本综述讨论了纤维素衍生物的起源、提取、制备及其在纳米颗粒制剂开发中的应用，这些纳米颗粒作为药物辅料具有多学科应用，并用于药物递送，因为细菌纤维素和植物纤维素在生物医学领域，包括牙科、蛋白质和肽递送、结直肠癌治疗以及3D可打印剂型中具有巨大的应用潜力。
