Department of Psychiatry and Behavioral Sciences, McGovern Medical School at the University of Texas Health Sciences Center at Houston, Houston, TX, USA.
The Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Psychiatry Res. 2018 Oct;268:400-412. doi: 10.1016/j.psychres.2018.08.012. Epub 2018 Aug 10.
Synthetic cannabinoid (SC) products have gained popularity as abused drugs over the past decade in many countries. The SCs broadly impact psychological state (e.g., mood, suicidal thoughts and psychosis) and physiological functions (e.g., cardiovascular, gastrointestinal and urinary). This review is about the effects of SCs on psychotic symptoms in clinical settings and the potentially relevant chemistry and mechanisms of action for SCs. Induction of psychotic symptoms after consuming SC products were reported, including new-onset psychosis and psychotic relapses. The role of SCs in psychosis is more complex than any single chemical component might explain, and these effects may not be a simple extension of the typical effects of cannabis or natural cannabinoids.
合成大麻素（SC）产品在过去十年中在许多国家作为滥用药物而广受欢迎。SC 广泛影响心理状态（例如，情绪、自杀念头和精神病）和生理功能（例如，心血管、胃肠道和泌尿系统）。这篇综述是关于 SC 对临床环境中的精神病症状的影响，以及 SC 相关的潜在化学和作用机制。有报道称，在使用 SC 产品后会出现精神病症状，包括首发精神病和精神病复发。SC 在精神病中的作用比任何单一化学成分都要复杂，这些影响可能不仅仅是大麻或天然大麻素的典型影响的简单延伸。
