Ohishi Y, Machida T, Kido A, Tashiro K, Wada T, Torii S, Yoshigoe F, Yamada H, Chiba K, Toyama H
Radioisotopes. 1986 Mar;35(3):115-21. doi: 10.3769/radioisotopes.35.3_115.
Renal function was assessed by measurement of 99mTc-dimercaptosuccinic acid (DMSA) uptake by the kidney based on the transsectional tomographic image obtained by single photon emission computed tomography (SPECT). The renal uptake was expressed as percentage of the total radioactivity detected in the kidney, the volume of which was measured by convolution method, against the amount dosed. Absorption was corrected by GE-STAR method using cut off level of 42%. In order to determine normal range, measurement was made for 40 kidneys of each of 10 male and female volunteers confirmed of having normal kidneys both morphologically and functionally. The average volume of the kidney was 220.4 ml for the right and 239.3 ml for the left for males, and 205.9 ml and 236.5 ml, respectively for females. The renal uptake of radioactivity (at 2 h after injection), was 26.8% for the right and 27.6% for the left for males, with corresponding figures for females being 26.4% and 27.9%, respectively. Distribution range of renal volume and renal uptake was obtained by bivariate analysis with 90% and 95% probability. From these results, our method of renal function determination based on renal uptake of 99mTc-DMSA obtained from renal transactional tomogram by SPECT is considered to be accurate and potentially useful for clinical purpose.
基于单光子发射计算机断层扫描（SPECT）获得的断层图像，通过测量肾脏对99mTc-二巯基丁二酸（DMSA）的摄取来评估肾功能。肾脏摄取量表示为肾脏中检测到的总放射性的百分比，其体积通过卷积法测量，相对于给药量。使用42%的截止水平通过GE-STAR方法校正吸收。为了确定正常范围，对10名男性和女性志愿者的40个肾脏进行了测量，这些志愿者在形态和功能上均被确认为肾脏正常。男性右肾平均体积为220.4毫升，左肾为239.3毫升，女性分别为205.9毫升和236.5毫升。男性放射性物质的肾脏摄取量（注射后2小时），右肾为26.8%，左肾为27.6%，女性相应数字分别为26.4%和27.9%。通过双变量分析获得了90%和95%概率下肾脏体积和肾脏摄取的分布范围。从这些结果来看，我们基于SPECT肾脏断层图像获得的99mTc-DMSA肾脏摄取来测定肾功能的方法被认为是准确的，并且可能对临床目的有用。
