Oishi Y, Tashiro K, Kishimoto K, Wada T, Torii S, Yoshigoe F, Machida T, Yamada H, Toyama H
Department of Urology, Jikei University, School of Medicine.
Hinyokika Kiyo. 1987 Nov;33(11):1749-54.
To determine renal function, 99mTc-DMSA renal uptake was measured from renal tomographic images obtained by single photon emission computed tomography (SPECT). A total of 77 tests was conducted on 73 patients with various diseases in the kidneys and urinary tract to determine renal uptake. The correlation coefficient(r) between total renal volume and total renal uptake was 0.3509 and that between renal volume and uptake of 143 kidneys was 0.5433. In 62 patients whose creatinine clearance could be measured, the correlation coefficient between creatinine clearance and total renal volume was 0.2352, and that between creatinine clearance and total renal uptake was 0.8854, that is, creatinine clearance correlated well with renal uptake. Renal volume and uptake determined in 10 normal male and 10 normal female adults were 220 ml and 26.8% for the right kidney and 239 ml and 27.6% for the left kidney for the males and 206 ml and 26.4% (right) and 237 ml and 27.9% (left) for the females. This method, which requires no blood or urine collection, is very useful as an individual kidney function test to evaluate individual kidney function and to understand kidney function before and after operation in patients with renal and urinary diseases.
为了测定肾功能，通过单光子发射计算机断层扫描（SPECT）获得的肾脏断层图像来测量99mTc - DMSA肾摄取。对73例患有各种肾脏和泌尿系统疾病的患者总共进行了77次测试以测定肾摄取。总肾体积与总肾摄取之间的相关系数（r）为0.3509，143个肾脏的肾体积与摄取之间的相关系数为0.5433。在62例可测量肌酐清除率的患者中，肌酐清除率与总肾体积之间的相关系数为0.2352，肌酐清除率与总肾摄取之间的相关系数为0.8854，即肌酐清除率与肾摄取相关性良好。10名正常男性和10名正常女性成年人测定的肾体积和摄取情况为：男性右肾为220 ml和26.8%，左肾为239 ml和27.6%；女性右肾为206 ml和26.4%，左肾为237 ml和27.9%。这种方法无需采集血液或尿液，作为一种个体肾功能测试，对于评估个体肾功能以及了解肾脏和泌尿系统疾病患者手术前后的肾功能非常有用。
