Sugiyama Y, Yotsumoto H, Takaku F
Respiration. 1986;49(4):292-5. doi: 10.1159/000194893.
Smoking is known to have various effects on metabolic function as well as on the respiratory function in the lung. We report here that exposure to smoke causes a rapid elevation of the level of serum angiotensin-converting enzyme in dogs in vivo. In 7 dogs, the level of serum angiotensin-converting enzyme increased from a basal level of 11.0 +/- 5.0 to 13.9 +/- 4.0 U/ml after 60 min of exposure (mean +/- SD, p less than 0.01). A similar elevation of serum angiotensin-converting enzyme level was noted in dogs that received an intravenous administration of nicotine. The possible mechanism of the change is discussed.
众所周知，吸烟对代谢功能以及肺部呼吸功能有多种影响。我们在此报告，在体内，接触烟雾会使犬血清血管紧张素转换酶水平迅速升高。在7只犬中，接触60分钟后，血清血管紧张素转换酶水平从基础水平11.0±5.0升高至13.9±4.0 U/ml（平均值±标准差，p<0.01）。在静脉注射尼古丁的犬中也观察到血清血管紧张素转换酶水平有类似升高。文中讨论了这种变化的可能机制。
