Department of Cardiology, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 510080, Guangzhou, China.
J Hum Hypertens. 2018 Nov;32(11):775-780. doi: 10.1038/s41371-018-0097-3. Epub 2018 Aug 20.
Recently, miRNAs have emerged as new indirect markers of inflammation that are associated with adverse outcomes in cardiovascular disease. The aim of the study was to evaluate the relationship between miR29a and proteinuria in hypertension. Fifty patients with normal albuminuria, fifty patients with micro-albuminuria, and fifty patients with macro-albuminuria were enrolled. The highest levels of miR-29a and transforming growth factor-β1 (TGF-β1) were observed in the macro-albuminuria group, followed by the micro-albuminuria and the normal albuminuria groups. The level of miR-29a was negatively correlated with the glomerular filtration rate, but was positively correlated with C-reactive protein, TGF-β1, and the urinary albumin to creatinine ratio (UACR). Circulating miR-29a was found to be significantly and independently associated with proteinuria. Our findings showed that miR-29a reflects the pathogenesis of hypertensive nephropathy and may serve as a potential non-invasive marker for detecting early stages of hypertensive nephropathy.
最近，miRNA 作为炎症的新的间接标志物出现，与心血管疾病的不良结局相关。本研究旨在评估 miR29a 与高血压蛋白尿之间的关系。纳入了 50 名正常白蛋白尿患者、50 名微量白蛋白尿患者和 50 名大量白蛋白尿患者。miR-29a 和转化生长因子-β1（TGF-β1）水平最高的是大量白蛋白尿组，其次是微量白蛋白尿组和正常白蛋白尿组。miR-29a 水平与肾小球滤过率呈负相关，与 C 反应蛋白、TGF-β1 和尿白蛋白与肌酐比值（UACR）呈正相关。循环 miR-29a 与蛋白尿显著且独立相关。我们的研究结果表明，miR-29a 反映了高血压肾病的发病机制，可能作为检测高血压肾病早期阶段的潜在非侵入性标志物。
