秘鲁的甲型肝炎。儿童的作用。

Hepatitis A in Peru. The role of children.

作者信息

Kilpatrick M E, Escamilla J

出版信息

Am J Epidemiol. 1986 Jul;124(1):111-3. doi: 10.1093/oxfordjournals.aje.a114354.

DOI:10.1093/oxfordjournals.aje.a114354

Abstract

A serologic survey in 1983-1984 evaluated the presence of hepatitis A antibody (anti-HAV) and hepatitis A immunoglobulin M antibody (anti-HAV IgM) in 3,251 adults and 811 children in the jungle and coastal areas of Peru. All subjects were asymptomatic. Adults had a 98% positive anti-HAV rate except for naval cadets, who had a 76% rate. Children had an 82% positive anti-HAV rate, increasing from 30% at one year of age to 100% at eight years of age. Anti-HAV IgM was present in 27% of children one to four years of age who had antibody and was not present in those older than 12. The vast majority of Peruvian adults are immune to hepatitis A, and children with asymptomatic infection play a significant role in the transmission of this disease.

摘要

1983年至1984年的一项血清学调查评估了秘鲁丛林和沿海地区3251名成年人及811名儿童中甲型肝炎抗体（抗-HAV）和甲型肝炎免疫球蛋白M抗体（抗-HAV IgM）的存在情况。所有受试者均无症状。成年人的抗-HAV阳性率为98%，海军学员除外，其阳性率为76%。儿童的抗-HAV阳性率为82%，从1岁时的30%增至8岁时的100%。1至4岁有抗体的儿童中，27%存在抗-HAV IgM，12岁以上儿童则未检测到。绝大多数秘鲁成年人对甲型肝炎具有免疫力，无症状感染的儿童在该疾病传播中起重要作用。