Cabibel Rodolphe, Gerard Ludovic, Maiter Dominique, Collin Vincent, Hantson Philippe
From the Departments of Intensive Care.
Endocrinology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
A A Pract. 2019 Mar 1;12(5):155-159. doi: 10.1213/XAA.0000000000000871.
Volatile anesthetic agents, such as sevoflurane, are increasingly used for long-term sedation in intensive care units worldwide, with improved clinical outcomes reported in recent studies due to favorable pharmacological properties. Despite possible renal toxicity related to the production of plasma inorganic fluoride and concerns related to reversible impairment of renal concentrating abilities, renal injury associated with sevoflurane sedation has rarely been reported in the intensive care unit setting. We hereby report 3 cases of nephrogenic diabetes insipidus associated with prolonged sevoflurane sedation using the AnaConDa device and review the possible mechanisms of renal toxicity.
挥发性麻醉剂，如七氟醚，在全球重症监护病房中越来越多地用于长期镇静，近期研究报告称由于其良好的药理学特性，临床结果有所改善。尽管与血浆无机氟生成相关可能存在肾毒性，且存在与肾浓缩能力可逆性损害相关的担忧，但在重症监护病房环境中，与七氟醚镇静相关的肾损伤鲜有报道。我们在此报告3例使用AnaConDa设备进行长时间七氟醚镇静后发生肾性尿崩症的病例，并探讨肾毒性的可能机制。
