Department of Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri.
Department of Medicine, University of Minnesota, Minnesota.
Biol Blood Marrow Transplant. 2018 Oct;24(10):1965-1970. doi: 10.1016/j.bbmt.2018.08.015. Epub 2018 Aug 18.
Hematopoietic cell transplantation (HCT) is increasingly utilized as a treatment for malignancies in the elderly population. At the same time, research has elucidated the impacts of HCT on bone marrow progenitor cells, one of which is accelerated aging. Clonal hematopoiesis has also been observed to occur in the aging population, both with and without HCT. The interplay between natural aging, clonal hemoatpoiesis, and the effects of HCT on the bone marrow, has not yet been addressed. Herein we explore this relationship, and its important clinical implications.
造血细胞移植（HCT）越来越多地被用于治疗老年人群的恶性肿瘤。与此同时，研究也阐明了 HCT 对骨髓祖细胞的影响，其中之一是加速衰老。在没有 HCT 的情况下，也会在老年人群中观察到克隆性造血。自然衰老、克隆性造血和 HCT 对骨髓的影响之间的相互作用尚未得到解决。本文探讨了这种关系及其重要的临床意义。
