儿童、青少年和青年的国际睾丸癌发病率
International testicular cancer incidence rates in children, adolescents and young adults.
作者信息
Kusler Kari A, Poynter Jenny N
机构信息
Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
出版信息
Cancer Epidemiol. 2018 Oct;56:106-111. doi: 10.1016/j.canep.2018.08.002. Epub 2018 Aug 18.
BACKGROUND
Testicular cancer is the most common cancer in young men in developed countries. In adults, international variation in testicular cancer incidence rates has been well-described, while previous research on pediatric and adolescent testicular cancer has been more geographically limited.
METHODS
In this analysis, we used data from the three most recent volumes of Cancer Incidence in Five Continents (CI5) and the National Cancer Institute's SEER 18 registries to compare incidence rates for testicular cancer in children (ages 0-14) and adolescents and young adults (AYA; ages 15-39).
RESULTS
We find that geographic incidence patterns in AYA are different from patterns in children under 15. In AYA, incidence is highest in Europe (137.4 per million), followed by Oceania (116.9 per million), North America (94.9 per million), South and Central America (66.5 per million), and lowest in Asia (27.1 per million). In contrast, childhood incidence is highest in Asia (4.2 per million) and South America (5.0 per million) and lowest in Europe (2.1 per million) and North America (2.5 per million). In the United States, patterns in incidence rates in racial and ethnic groups mirror international rates.
CONCLUSION
These differences in incidence rate variations in pediatric and AYA testicular cancer are intriguing and may aid in understanding the different etiologies of testicular cancer by age group.
背景
睾丸癌是发达国家年轻男性中最常见的癌症。在成年人中，睾丸癌发病率的国际差异已有充分描述，而此前关于儿童和青少年睾丸癌的研究在地域上更为有限。
方法
在本分析中，我们使用了《五大洲癌症发病率》（CI5）最近三卷的数据以及美国国立癌症研究所的监测、流行病学和最终结果（SEER）18个登记处的数据，以比较儿童（0至14岁）以及青少年和青年（15至39岁）睾丸癌的发病率。
结果
我们发现，青少年和青年的地理发病率模式与15岁以下儿童的模式不同。在青少年和青年中，欧洲的发病率最高（每百万137.4例），其次是大洋洲（每百万116.9例）、北美洲（每百万94.9例）、南美洲和中美洲（每百万66.5例），亚洲最低（每百万27.1例）。相比之下，儿童期发病率在亚洲（每百万4.2例）和南美洲（每百万5.0例）最高，在欧洲（每百万2.1例）和北美洲（每百万2.5例）最低。在美国，不同种族和族裔群体的发病率模式与国际发病率模式相似。
结论
儿童和青少年及青年睾丸癌发病率变化的这些差异很有趣，可能有助于了解不同年龄组睾丸癌的不同病因。
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