Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan; Advanced Trauma, Emergency and Critical Care Center, Faculty of Medicine, Oita University, Oita, Japan.
Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan.
J Affect Disord. 2018 Dec 1;241:200-205. doi: 10.1016/j.jad.2018.08.006. Epub 2018 Aug 9.
Previous studies have investigated the effects of omega-3, omega-6 and lithium on suicide-related behaviors separately. This study was performed to comprehensively investigate the effects of naturally absorbed EPA, DHA, arachidonic acid and lithium in relation to suicide attempt and deliberate self-harm, with adjustment for each other.
We analyzed plasma EPA, DHA, arachidonic acid levels and serum lithium levels of 197 patients including 33 patients with suicide attempts, 18 patients with deliberate self-harm, and 146 control patients.
Multivariate logistic regression analysis with adjustment for age, gender, EPA, DHA, arachidonic acid and log-transformed lithium levels revealed that the negative associations with EPA levels (adjusted OR 0.972, 95% CI 0.947-0.997, p = 0.031) and log-transformed lithium levels (adjusted OR 0.156, 95% CI 0.038-0.644, p = 0.01) and the positive association with DHA levels (adjusted OR 1.026, 95% CI 1.010-1.043, p = 0.002) were significant in patients with suicide attempts than in control patients. The analysis also demonstrated that the positive association with arachidonic acid levels (adjusted OR 1.015, 95% CI 1.005-1.025, p = 0.004) was significant in patients with deliberate self-harm than in control patients.
The limitations are relatively small number of patients and the effects of demographics of individual patients could not be adjusted for the analyses.
The present findings suggest that, as naturally absorbed nutrients, higher EPA and lithium levels may be associated with less suicide attempt, and that higher arachidonic acid levels may be associated with more deliberate self-harm.
先前的研究分别探讨了 ω-3、ω-6 和锂对自杀相关行为的影响。本研究旨在综合调查天然吸收的 EPA、DHA、花生四烯酸和锂与自杀未遂和蓄意自残的关系，并相互调整。
我们分析了 197 名患者的血浆 EPA、DHA、花生四烯酸水平和血清锂水平，包括 33 名自杀未遂患者、18 名蓄意自残患者和 146 名对照患者。
多变量逻辑回归分析调整年龄、性别、EPA、DHA、花生四烯酸和对数转换锂水平后，发现与 EPA 水平呈负相关（调整后 OR 0.972，95%CI 0.947-0.997，p=0.031）和对数转换锂水平（调整后 OR 0.156，95%CI 0.038-0.644，p=0.01）以及与 DHA 水平呈正相关（调整后 OR 1.026，95%CI 1.010-1.043，p=0.002）在自杀未遂患者中比在对照患者中更为显著。分析还表明，与花生四烯酸水平呈正相关（调整后 OR 1.015，95%CI 1.005-1.025，p=0.004）在蓄意自残患者中比在对照患者中更为显著。
患者数量相对较少，且无法调整个别患者的人口统计学因素对分析的影响。
本研究结果表明，作为天然吸收的营养素，较高的 EPA 和锂水平可能与自杀未遂的可能性降低有关，而较高的花生四烯酸水平可能与蓄意自残的可能性增加有关。
