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高效液相色谱法测定美洛西林及其青霉酸酯和青霉醛酸酯以及美洛西林在不同温度下的稳定性

Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures.

作者信息

Knöller J, Bremm K D, Schönfeld W, König W

出版信息

Antimicrob Agents Chemother. 1986 Mar;29(3):527-9. doi: 10.1128/AAC.29.3.527.

DOI:10.1128/AAC.29.3.527
PMID:3013089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180429/
Abstract

A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography. The stability of mezlocillin in serum and buffer was studied at different temperatures (4, -20, -70, and -196 degrees C) over a period of 6 months. Mezlocillin remained stable at -70 and -196 degrees C, whereas degradation was observed at -20 and 4 degrees C in serum and buffer.

摘要

描述了一种通过高效液相色谱法测定生物流体中美洛西林及其代谢产物青霉噻唑酸和青霉烯酸的方法。研究了美洛西林在血清和缓冲液中于不同温度（4、-20、-70和-196℃）下6个月期间的稳定性。美洛西林在-70和-196℃下保持稳定，而在血清和缓冲液中于-20和4℃观察到降解。

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Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures.高效液相色谱法测定美洛西林及其青霉酸酯和青霉醛酸酯以及美洛西林在不同温度下的稳定性
Antimicrob Agents Chemother. 1986 Mar;29(3):527-9. doi: 10.1128/AAC.29.3.527.
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[Mezlocillin: a penicillin from the acylureido series. Synthesis and chemical properties].
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Degradation of acylaminopenicillins with regard to their pH dependency.酰基氨基青霉素在pH依赖性方面的降解
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Stability of mezlocillin sodium as determined by high-performance liquid chromatography.采用高效液相色谱法测定美洛西林钠的稳定性。
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High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers.健康志愿者血浆和尿液中美洛西林、哌拉西林及其降解产物以及碘他拉酸的高效液相色谱分析。
Arzneimittelforschung. 1985;35(7):1099-104.

引用本文的文献

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Dose-dependent pharmacokinetics of mezlocillin in rats.美洛西林在大鼠体内的剂量依赖性药代动力学
Antimicrob Agents Chemother. 1989 Jun;33(6):839-43. doi: 10.1128/AAC.33.6.839.

本文引用的文献

1
High-pressure liquid chromatographic quantitation of azlocillin.阿洛西林的高压液相色谱定量分析
Antimicrob Agents Chemother. 1983 Nov;24(5):750-3. doi: 10.1128/AAC.24.5.750.
2
Improved micromethod for mezlocillin quantitation in serum and urine by high-pressure liquid chromatography.高压液相色谱法测定血清和尿液中美洛西林的改进微量方法。
Antimicrob Agents Chemother. 1984 Nov;26(5):775-7. doi: 10.1128/AAC.26.5.775.
3
Improved procedure for the determination of the ureidopenicillins azlocillin and mezlocillin plasma by high-performance liquid chromatography.
J Chromatogr. 1982 Mar 12;228:409-12. doi: 10.1016/s0378-4347(00)80464-8.
4
Degradation of azlocillin in human serum.阿洛西林在人血清中的降解
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Oct;260(2):254-9. doi: 10.1016/s0176-6724(85)80122-x.
5
Determination of the ureidopenicillins azlocillin, mezlocillin and bay K 4999 in plasma by high performance liquid chromatography.用高效液相色谱法测定血浆中脲基青霉素阿洛西林、美洛西林和Bay K 4999。
Br J Clin Pharmacol. 1979 Dec;8(6):589-92. doi: 10.1111/j.1365-2125.1979.tb01049.x.