高效液相色谱法测定美洛西林及其青霉酸酯和青霉醛酸酯以及美洛西林在不同温度下的稳定性
Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures.
作者信息
Knöller J, Bremm K D, Schönfeld W, König W
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):527-9. doi: 10.1128/AAC.29.3.527.
Abstract
A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography. The stability of mezlocillin in serum and buffer was studied at different temperatures (4, -20, -70, and -196 degrees C) over a period of 6 months. Mezlocillin remained stable at -70 and -196 degrees C, whereas degradation was observed at -20 and 4 degrees C in serum and buffer.
摘要
描述了一种通过高效液相色谱法测定生物流体中美洛西林及其代谢产物青霉噻唑酸和青霉烯酸的方法。研究了美洛西林在血清和缓冲液中于不同温度（4、-20、-70和-196℃）下6个月期间的稳定性。美洛西林在-70和-196℃下保持稳定，而在血清和缓冲液中于-20和4℃观察到降解。
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Improved procedure for the determination of the ureidopenicillins azlocillin and mezlocillin plasma by high-performance liquid chromatography.
J Chromatogr. 1982 Mar 12;228:409-12. doi: 10.1016/s0378-4347(00)80464-8.
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Degradation of azlocillin in human serum.阿洛西林在人血清中的降解
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Br J Clin Pharmacol. 1979 Dec;8(6):589-92. doi: 10.1111/j.1365-2125.1979.tb01049.x.
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