INSERM U1151-CNRS UMR 8253, Institut Necker-Enfants Malades (INEM), Paris, France.
Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
EMBO Rep. 2018 Sep;19(9). doi: 10.15252/embr.201846858. Epub 2018 Aug 21.
Autophagosome biogenesis is the key event associated with the stress‐responsive autophagic pathway, allowing the capture of specific cargoes and their delivery to the lysosomal degradative compartment. Although the endoplasmatic reticulum (ER) appears to be central for the assembly of autophagosomal membranes, it is also involved in several events regulating trafficking and local signaling, e.g., the establishment of contact sites with other organelles, the vesicular transport to the Golgi apparatus, and the biogenesis and turnover of lipid droplets. In this issue of , Moretti 1 identify the ER transmembrane protein TMEM41B as a novel regulator of autophagosome biogenesis and unravel its involvement in lipid droplet dynamics, also highlighting the role of ER components at the interface of lipid metabolism and regulation of autophagy.
自噬体生物发生是与应激反应性自噬途径相关的关键事件，允许捕获特定的货物并将其递送至溶酶体降解隔室。尽管内质网 (ER) 似乎是自噬体膜组装的核心，但它也参与调节运输和局部信号转导的几个事件，例如与其他细胞器建立接触位点、囊泡运输到高尔基器，以及脂滴的生物发生和周转。在本期的《细胞》杂志中，Moretti 1 鉴定内质网跨膜蛋白 TMEM41B 为自噬体生物发生的新调节剂，并揭示其在脂滴动力学中的作用，同时强调 ER 成分在脂代谢和自噬调节界面的作用。
