用于生物医学应用的纳米工程热响应磁性水凝胶。

Jalili Nima A, Muscarello Madyson, Gaharwar Akhilesh K

Dept. of Biomedical Engineering Texas A&M University, College Station TX 77843.

Dept. of Materials Science and Engineering Texas A&M University, College Station TX 77843.

Bioeng Transl Med. 2016 Oct 17;1(3):297-305. doi: 10.1002/btm2.10034. eCollection 2016 Sep.

"Smart" hydrogels are part of an emerging class of biomaterials that respond to multiple external stimuli. A range of thermoresponsive magnetic hydrogels is currently being developed for on-demand delivery of biomolecules for a range of biomedical applications, including therapeutic drug delivery, bioimaging, and regenerative engineering. In this review article, we explore different types of magnetic nanoparticles and thermoresponsive polymers used to fabricate these smart nanoengineered hydrogels. We highlight some of the emerging applications of these stimuli-responsive hydrogels for biomedical applications. Finally, we capture the growing trend of these smart nanoengineered hydrogels and will identify promising new research directions.

“智能”水凝胶是一类新兴生物材料的一部分，这类材料能够对多种外部刺激做出响应。目前正在研发一系列热响应性磁性水凝胶，用于按需递送生物分子，以应用于一系列生物医学领域，包括治疗性药物递送、生物成像和再生工程。在这篇综述文章中，我们探讨了用于制造这些智能纳米工程水凝胶的不同类型的磁性纳米颗粒和热响应性聚合物。我们重点介绍了这些刺激响应性水凝胶在生物医学应用中的一些新兴应用。最后，我们把握了这些智能纳米工程水凝胶的发展趋势，并将确定有前景的新研究方向。