Peng Dandan, Wang Xiaomin, Xu Yannan, Sun Chenhui, Zhou Xudong
a School of Public Health , Zhejiang University , Hangzhou , PR China.
Glob Health Action. 2018;11(1):1496973. doi: 10.1080/16549716.2018.1496973.
Antimicrobial resistance (AMR) is a great threat to public health. The primary cause of AMR is human antibiotic misuse. Little is known about regional differences of antibiotic misuse behaviours in China.
To explore the antibiotic misuse behaviours among university students in western and eastern China and find out the regional differences.
Participants were recruited from universities in less developed Guizhou Province and developed Zhejiang Province using a cluster random sampling method. A self-administered questionnaire was designed to collect data, and the χ test and logistic regression were adopted to assess the associations between region and antibiotic misuse behaviours.
A total of 2073 university students from Guizhou and 1922 from Zhejiang completed questionnaires. Students in Guizhou had lower household income, parents' education, and urban residence proportion than those in Zhejiang. Compared with those in Zhejiang, students in Guizhou had higher antibiotic use prescribed by doctors (79.8% vs 56.2%) and self-medication with antibiotics (33.0% vs 16.1%). Students in Guizhou were more likely to buy over-the-counter antibiotics without prescriptions (73.9% vs 63.4%), ask for antibiotics from doctors (21.4% vs 15.6%), and use antibiotics prophylactically (29.9% vs 15.7%). Adjusted models showed that the less developed region was significantly associated with higher antibiotic misuse behaviours.
Misuse of antibiotics by well-educated young adults was very high in two regions but most serious in the less developed one. Campaigns are urgently needed to promote appropriate antibiotic use especially in less developed regions.
抗菌药物耐药性（AMR）对公众健康构成巨大威胁。AMR的主要原因是人类抗生素滥用。关于中国抗生素滥用行为的地区差异知之甚少。
探讨中国西部和东部大学生的抗生素滥用行为，并找出地区差异。
采用整群随机抽样方法，从欠发达的贵州省和发达的浙江省的大学中招募参与者。设计了一份自填式问卷来收集数据，并采用χ检验和逻辑回归来评估地区与抗生素滥用行为之间的关联。
来自贵州的2073名大学生和来自浙江的1922名大学生完成了问卷。贵州学生的家庭收入、父母教育程度和城市居住比例低于浙江学生。与浙江学生相比，贵州学生医生处方使用抗生素的比例更高（79.8%对56.2%），自我使用抗生素的比例更高（33.0%对16.1%）。贵州学生更有可能无处方购买非处方抗生素（73.9%对63.4%），向医生索要抗生素（21.4%对15.6%），以及预防性使用抗生素（29.9%对15.7%）。调整后的模型显示，欠发达地区与更高的抗生素滥用行为显著相关。
在这两个地区，受过良好教育的年轻人抗生素滥用情况非常严重，但在欠发达地区最为严重。迫切需要开展宣传活动，以促进合理使用抗生素，特别是在欠发达地区。
