School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
Int J Antimicrob Agents. 2017 Sep;50(3):441-446. doi: 10.1016/j.ijantimicag.2017.04.009. Epub 2017 Jun 28.
Antimicrobial resistance (AMR) is one of the greatest threats to global health this century. The primary cause of AMR is antibiotic misuse, especially routine use of antibiotics for self-limiting illnesses. This study aimed to explore behaviours related to antibiotic use in university students across China. An electronic questionnaire was distributed at a major university in each of the six regions. A cluster random sampling method was adopted. The χ test and logistic regression were used to assess the relationship between knowledge and behaviour. A total of 11,192 students completed the questionnaire. In the past month, 3337 students (29.8%) reported a self-limiting illness, of whom 913 (27.3%) saw a doctor, 600 (65.7%) of whom were prescribed antibiotics [190 (31.7%) by infusion]; 136 students (22.7%) asked for and received antibiotics. Of the 1711 students (51.3%) who treated themselves, 507 (29.6%) self-medicated with antibiotics. In the past year, 23.0% of students had used antibiotics as prophylaxis, 63.1% kept a personal stock of antibiotics and 56.0% had bought antibiotics at a drugstore (two-thirds without a prescription). Students with lower knowledge scores about antibiotics were significantly more likely to see a doctor, be prescribed with antibiotics, self-medicate with antibiotics, and use antibiotics prophylactically. This massive misuse of antibiotics for self-limiting illnesses by well-educated young adults is a serious concern. A national campaign is urgently required to address rational prescribing of antibiotics by doctors, enforce existing restrictions on over-the-counter sale of antibiotics, and educate the general public about antibiotics and the management of self-limiting illnesses.
抗微生物药物耐药性（AMR）是本世纪全球健康面临的最大威胁之一。AMR 的主要原因是抗生素的滥用，特别是将抗生素常规用于自限性疾病。本研究旨在探讨中国大学生抗生素使用相关行为。在六个地区的一所主要大学中采用电子问卷调查。采用聚类随机抽样方法。采用 χ 检验和逻辑回归评估知识与行为之间的关系。共有 11192 名学生完成了问卷。在过去一个月中，3337 名学生（29.8%）报告患有自限性疾病，其中 913 名（27.3%）就医，其中 600 名（65.7%）开了抗生素[190 名（31.7%）静脉滴注]；136 名学生（22.7%）要求并获得了抗生素。在 1711 名（51.3%）自行治疗的学生中，507 名（29.6%）自行使用抗生素。在过去一年中，23.0%的学生预防性使用抗生素，63.1%的学生储备个人抗生素，56.0%的学生在药店购买抗生素（三分之二无处方）。抗生素知识得分较低的学生更有可能就医、开抗生素处方、自行用抗生素治疗、预防性使用抗生素。这种受过良好教育的年轻人对自限性疾病大量滥用抗生素是一个严重的问题。迫切需要开展全国性运动，解决医生合理开具抗生素处方的问题，执行现有对抗生素非处方销售的限制，并教育公众了解抗生素和自限性疾病的管理。
