SilE 模型在 Ag(His)(Met) 基序形成时的α-螺旋折叠。
Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation.
机构信息
University of Fribourg, Department of Chemistry, Chemin du Musée 9, 1700 Fribourg, Switzerland.
出版信息
Chem Commun (Camb). 2018 Sep 13;54(74):10419-10422. doi: 10.1039/c8cc03784a.
PMID:30132476
Abstract
The SilE protein is suspected to have a prominent role in Ag+ detoxification of silver resistant bacteria. Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced α-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system.
摘要
SilE 蛋白被怀疑在银抗性细菌的 Ag+解毒中具有重要作用。使用模型肽，我们阐明了 SilE 中富含组氨酸和蛋氨酸的序列诱导 Ag+形成 α-螺旋结构的定性和定量方面，这提高了我们对其在 Sil 系统中功能的理解。
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