Gissmann L, Schwarz E
Ciba Found Symp. 1986;120:190-207. doi: 10.1002/9780470513309.ch13.
There is mounting evidence that certain types of human papillomaviruses (HPV types 16 and 18) are associated with human genital cancer. Other virus types, such as HPV-6 or HPV-11, are more regularly found in benign genital warts. Since all viruses can be present in putative precancerous lesions of the uterine cervix (dysplasia, cervical intraepithelial neoplasia) it has been postulated that individual HPV types have different 'oncogenic potential'. The molecular basis for this difference is not known. The question of the natural reservoir for the oncogenic viruses is discussed. Expression of parts of the early region of the HPV genome in cell lines established from genital cancer supports the hypothesis that papillomaviruses are involved in inducing and/or maintaining the transformed phenotype of cancer cells.
越来越多的证据表明，某些类型的人乳头瘤病毒（16型和18型人乳头瘤病毒）与人类生殖器癌有关。其他病毒类型，如HPV - 6或HPV - 11，在良性生殖器疣中更常见。由于所有病毒都可能存在于子宫颈假定的癌前病变（发育异常、宫颈上皮内瘤变）中，因此有人推测不同的人乳头瘤病毒类型具有不同的“致癌潜力”。这种差异的分子基础尚不清楚。本文讨论了致癌病毒的天然宿主问题。在从生殖器癌建立的细胞系中HPV基因组早期区域部分的表达支持了乳头瘤病毒参与诱导和/或维持癌细胞转化表型这一假说。
