生殖道中人乳头瘤病毒感染的生物学特性及意义

Cervical and Vulvar Dysplasia Unit, Sinai Hospital, Detroit, Michigan.

Yale J Biol Med. 1988 Jul-Aug;61(4):307-25.

A variety of human papillomavirus (HPV) types infect the anogenital mucosa, giving rise to lesions that differ in clinical appearance, histology, and risk of malignant progression. Certain high-risk types (HPVs 16, 18, 31, 33, 35 and 39) have a strong association with high-grade epithelial neoplasia and invasive carcinomas of the anogenital tract. Cancer appears to have a multifactorial etiology, and HPV infection alone is probably insufficient for malignant transformation. The consistent association between HPV infection and anogenital cancers emphasizes, however, that the sexually transmitted papillomaviruses may have a necessary role in carcinogenesis. Hence, there is a prospect that vaccination programs may one day allow public health control of HPV infection, thereby eliminating an important risk factor.

多种人类乳头瘤病毒（HPV）可感染肛门生殖器黏膜，引发临床外观、组织学和恶性进展风险各异的病变。某些高危型（HPV 16、18、31、33、35和39）与高级别上皮内瘤变及肛门生殖道浸润癌密切相关。癌症似乎具有多因素病因，仅HPV感染可能不足以导致恶性转化。然而，HPV感染与肛门生殖器癌之间的持续关联强调，性传播乳头瘤病毒可能在致癌过程中发挥必要作用。因此，有前景的是，疫苗接种计划或许有朝一日能实现对HPV感染的公共卫生控制，从而消除一个重要的风险因素。