Herrera G A, Wilkerson J A
Diagn Cytopathol. 1985 Oct-Dec;1(4):272-85. doi: 10.1002/dc.2840010405.
An ultrastructural study was performed on 104 sequential fluids in which more than eight malignant cells per ten high-power fields were found by routine light microscopy. The study included fluids associated with mesotheliomas, melanomas, lymphomas, squamous-cell carcinomas, small-cell anaplastic (oat-cell) carcinomas, and adenocarcinomas. Electron microscopic examination reliably separated lymphoid from epithelial malignancies and benign from reactive and malignant mesothelial cell proliferations. It also suggested or identified a primary site for the adenocarcinomas. Ultrastructural examination of fluids can be a valuable adjunct to routine light microscopy of cytology specimens. No false-positive diagnoses were encountered. Sampling was the most significant limitation for this technique.
对104份连续的体液进行了超微结构研究，这些体液通过常规光学显微镜检查发现每十个高倍视野中有超过八个恶性细胞。该研究包括与间皮瘤、黑色素瘤、淋巴瘤、鳞状细胞癌、小细胞间变性（燕麦细胞）癌和腺癌相关的体液。电子显微镜检查可靠地将淋巴样恶性肿瘤与上皮性恶性肿瘤区分开来，并将良性间皮细胞增殖与反应性和恶性间皮细胞增殖区分开来。它还提示或确定了腺癌的原发部位。体液的超微结构检查可以作为细胞学标本常规光学显微镜检查的有价值辅助手段。未遇到假阳性诊断。采样是该技术最显著的限制因素。
