Leong A S
Pathology. 1982 Jan;14(1):37-46. doi: 10.3109/00313028209069041.
Biopsies from 50 primary lung tumours were classified according to the World Health Organisation's Histological Typing of Lung Tumours. They were also subjected to electron microscopic examination. Comparison of the diagnoses made by these separate methods showed that many poorly differentiated squamous cell carcinomas had been incorrectly classified. Agreement was good in the diagnosis of adenocarcinoma whilst ultrastructural examination of small anaplastic carcinomas disclosed a neuroendocrine tumour with a combination of squamous and glandular elements. Large cell anaplastic carcinoma proved to be a 'waste-basket' containing tumours which displayed ultrastructural characteristics of poorly differentiated squamous cell carcinoma, poorly differentiated adenocarcinoma or neuroendocrine carcinoma. Electron microscopy was also valuable in characterization of other pulmonary tumours whose identity could not be resolved at the light microscopic level. Ultrastructural examination may provide a better understanding of the histogenesis and derivation of lung tumours, as well as their behaviour and therapeutic response.
根据世界卫生组织的《肺肿瘤组织学类型》，对50例原发性肺肿瘤的活检标本进行了分类。这些标本还接受了电子显微镜检查。对这两种不同方法做出的诊断进行比较后发现，许多低分化鳞状细胞癌被错误分类。在腺癌的诊断上，两种方法的一致性良好；而对小细胞间变性癌的超微结构检查发现，其为一种具有鳞状和腺性成分组合的神经内分泌肿瘤。大细胞间变性癌被证明是一个“杂物筐”，包含显示低分化鳞状细胞癌、低分化腺癌或神经内分泌癌超微结构特征的肿瘤。电子显微镜检查对于那些在光镜下无法明确诊断的其他肺部肿瘤的特征描述也很有价值。超微结构检查可能有助于更好地理解肺肿瘤的组织发生、起源，以及它们的行为和治疗反应。
