2016年日本千叶县婴儿感染柯萨奇病毒B5引发的无菌性脑膜炎
Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.
作者信息
Tsuno Kanae, Miyatake Chiharu, Nishijima Haruna, Hotta Chiemi, Ogawa Tomoko, Asano Takeshi
机构信息
Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital.
Division of Virology, Chiba Prefectural Institute of Public Health.
出版信息
J Nippon Med Sch. 2018;85(3):187-190. doi: 10.1272/jnms.JNMS.2018_85-28.
BACKGROUND
Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis.
CASE PRESENTATION
We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. In addition, viral analysis of sewage samples from Chiba Prefecture in 2016 showed similar 404-bp CVB5 VP1 sequences from May to September 2016.
CONCLUSION
These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains.
背景
婴儿无菌性脑膜炎是一种罕见的中枢神经系统感染。柯萨奇病毒B5（CVB5）是一种肠道病毒，有时与无菌性脑膜炎和脑炎有关。
病例报告
我们报告了2016年春夏期间3例由CVB5引起的无菌性脑膜炎的孤立婴儿病例，其CVB5病毒衣壳蛋白1（VP1）序列几乎相同，均为404bp。此外，对2016年千叶县污水样本的病毒分析显示，在2016年5月至9月期间，污水中存在相似的404bp CVB5 VP1序列。
结论
这些结果表明，对污水进行病毒筛查可能有助于检测病毒感染的隐匿性暴发，特别是对于肠道病毒株。
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