Papa A, Dumaidi K, Franzidou F, Antoniadis A
A' Department of Microbiology, School of Medicine, Aristotle University of Thessaloniki, Greece.
Clin Microbiol Infect. 2006 Jul;12(7):688-91. doi: 10.1111/j.1469-0691.2006.01476.x.
In order to explore the genetic relationships among coxsackie virus B5 strains in Greece, the nucleotide sequences of the partial VP1 gene in strains isolated from aseptic cases of meningitis were determined and compared with those of strains isolated from other countries. Phylogenetic analysis showed a high degree of divergence (25%) among Greek strains isolated in different years, which clustered with high bootstrap values in a different subgroup of viruses, suggesting that enterovirus types vary with time rather than geographical distribution. A non-synonymous mutation present in the strains of this study was not observed in other coxsackie virus B5 strains.
为了探究希腊柯萨奇病毒B5毒株之间的遗传关系，测定了从无菌性脑膜炎病例中分离出的毒株的部分VP1基因的核苷酸序列，并与从其他国家分离出的毒株进行了比较。系统发育分析表明，不同年份分离出的希腊毒株之间存在高度差异（25%），这些毒株在病毒的不同亚组中以高自展值聚类，这表明肠道病毒类型随时间变化而非地理分布而变化。本研究毒株中存在的一个非同义突变在其他柯萨奇病毒B5毒株中未观察到。
