作者更正：基因工程化的脑类器官模拟脑肿瘤形成。
Author Correction: Genetically engineered cerebral organoids model brain tumor formation.
作者信息
Bian Shan, Repic Marko, Guo Zhenming, Kavirayani Anoop, Burkard Thomas, Bagley Joshua A, Krauditsch Christian, Knoblich Jürgen A
机构信息
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria.
MC Toxicology Consulting, Vienna, Austria.
出版信息
Nat Methods. 2018 Sep;15(9):748. doi: 10.1038/s41592-018-0118-8.
Abstract
In the originally published paper, the "before" image for the afatinib condition in Fig. 6c was incorrect. Instead of an image displaying a GBM-3 neoplastic organoid before afatinib treatment, this panel showed an image from the GBM-2 control (DMSO) group before treatment. This error has now been corrected in the HTML and PDF versions of the article; the "before, afatinib" panel in Fig. 6c now shows a representative image from the indicated experiment. The color of all error bars in Fig. 6 has also been changed to black, for consistency. All statistical analysis and all conclusions presented in the article are unaffected by this error. Nevertheless, we apologize for the mistake.
摘要
在最初发表的论文中，图6c中阿法替尼条件下的“治疗前”图像有误。该图展示的不是阿法替尼治疗前的胶质母细胞瘤-3肿瘤类器官图像，而是治疗前GBM-2对照组（二甲基亚砜）的图像。此错误现已在文章的HTML和PDF版本中更正；图6c中“阿法替尼治疗前”板块现在显示的是指定实验的代表性图像。为保持一致，图6中所有误差线的颜色也已更改为黑色。文章中呈现的所有统计分析和所有结论均不受此错误影响。尽管如此，我们仍为这一错误表示歉意。
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本文引用的文献
1
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Biomaterials. 2018 Apr;161:164-178. doi: 10.1016/j.biomaterials.2018.01.053. Epub 2018 Feb 3.
2
Zika virus has oncolytic activity against glioblastoma stem cells.寨卡病毒对胶质母细胞瘤干细胞具有溶瘤活性。
J Exp Med. 2017 Oct 2;214(10):2843-2857. doi: 10.1084/jem.20171093. Epub 2017 Sep 5.
3
Fused cerebral organoids model interactions between brain regions.融合的大脑类器官可模拟脑区之间的相互作用。
Nat Methods. 2017 Jul;14(7):743-751. doi: 10.1038/nmeth.4304. Epub 2017 May 10.
4
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Neuro Oncol. 2016 Oct 1;18(suppl_5):v1-v75. doi: 10.1093/neuonc/now207.
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6
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