Pamies David, Zurich Marie-Gabrielle, Hartung Thomas
Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Swiss Centre for Applied Human Toxicology (SCAHT), Switzerland.
iScience. 2020 Oct 1;23(10):101633. doi: 10.1016/j.isci.2020.101633. eCollection 2020 Oct 23.
Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.
胶质母细胞瘤是成人中一种极具侵袭性的原发性脑肿瘤，生存率极低且尚无治愈性治疗方法。针对这种癌症的药物研发失败率高，与用于研究该疾病的高成本、耗时且低效的模型有关。然而，干细胞和培养技术的进展很有前景，在此我们介绍现有器官型培养模型的优缺点，并讨论它们在研究胶质母细胞瘤方面的可能应用。
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