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体外配子发生:捐卵的终结?

In vitro gametogenesis: The end of egg donation?

机构信息

Department of Politics, Philosophy and Religion, Lancaster University, Lancaster, United Kingdom.

出版信息

Bioethics. 2019 Jan;33(1):60-67. doi: 10.1111/bioe.12499. Epub 2018 Aug 23.

DOI:10.1111/bioe.12499
PMID:30136749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6491990/
Abstract

This paper explores whether egg donation could still be ethically justified if in vitro gametogenesis (IVG) became reliable and safe. In order to do this, issues and concerns that might inform a patient's reasoning in choosing to use donor eggs instead of IVG are explored and assessed. It is concluded that egg donation would only be ethically justified in a narrow range of special cases given the (hypothetical) availability of IVG treatment and, further, that egg donation could itself be replaced by donation through IVG techniques. Two possible criticisms of this position are then considered: Ones based on respect for patient wishes, and on loss of donor benefit. It is concluded that whilst neither argument constitutes a strong enough reason to continue with programmes of egg donation, egg-sharing programmes could still be permitted come the advent of IVG; these could then provide a morally acceptable source of "natural" donor eggs.

摘要

本文探讨了如果体外配子发生(IVG)变得可靠和安全,那么卵子捐赠是否仍然在伦理上是合理的。为此,探讨并评估了可能影响患者选择使用捐赠卵子而不是 IVG 的原因和关注点。结论是,鉴于(假设)IVG 治疗的可用性,卵子捐赠仅在有限的特殊情况下在伦理上是合理的,而且,卵子捐赠本身可以通过 IVG 技术的捐赠来替代。然后考虑了对这一立场的两种可能的批评:一种基于对患者意愿的尊重,另一种基于捐赠者利益的丧失。结论是,虽然这两个论点都不足以成为继续进行卵子捐赠计划的充分理由,但随着 IVG 的出现,仍然可以允许卵子共享计划;这些计划随后可以提供一个道德上可接受的“自然”供体卵子来源。

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Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.医学中表观基因组编辑与基因组编辑的比较伦理评估:初步步骤与未来方向
J Med Ethics. 2024 May 22;50(6):398-406. doi: 10.1136/jme-2022-108888.
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In Vitro Gametogenesis in Oncofertility: A Review of Its Potential Use and Present-Day Challenges in Moving toward Fertility Preservation and Restoration.肿瘤生育学中的体外配子发生:迈向生育力保存与恢复的潜在用途及当前挑战综述
J Clin Med. 2023 May 6;12(9):3305. doi: 10.3390/jcm12093305.
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Enthusiasm, concern and ambivalence in the Belgian public's attitude towards in-vitro gametogenesis.比利时公众对体外配子发生态度中的热情、关注与矛盾情绪。
Reprod Biomed Soc Online. 2021 Nov 25;14:156-168. doi: 10.1016/j.rbms.2021.10.005. eCollection 2022 Mar.