a Department of Medicine , University of Chicago , Chicago , IL , USA.
b Biomedical Sciences Program, College of Health Sciences , Midwestern University , Downers Grove , IL , USA.
Gut Microbes. 2019;10(2):235-240. doi: 10.1080/19490976.2018.1502539. Epub 2018 Aug 23.
Our recently published paper "Small Intestine Microbiota Regulate Digestive and Absorptive Adaptive Responses to Dietary Lipids" in Cell Host & Microbe explored the neglected small intestine microbiota and demonstrated its critical role as a regulator of fat digestion and absorption. This work generated the following important take home messages: 1) small intestinal microbes are particularly sensitive to high fat diets and turn on host processes regulating fat digestion and transport, 2) this action is very likely orchestrated by a consortium of microbes, each having different specific effects and targets, and 3) the actions of this consortium appear to be mediated by bacteria-derived small molecules or bioactive components. These findings are expected to provide insight into developing treatments for conditions of under- or over-nutrition. The goal of this addendum is to summarize our findings, address issues related to gut microbiota and gnotobiotic research specifically regarding technology and experimental design, discuss this work in the context of relevant literature, and lastly provide considerations for future research.
我们最近在《Cell Host & Microbe》杂志上发表的题为“Small Intestine Microbiota Regulate Digestive and Absorptive Adaptive Responses to Dietary Lipids”的论文探讨了被忽视的小肠微生物群，并证实了其作为脂肪消化和吸收调节剂的关键作用。这项工作得出了以下重要结论：1）小肠微生物对高脂肪饮食特别敏感，并启动宿主调节脂肪消化和运输的过程，2）这种作用很可能是由一群微生物协调的，每个微生物都有不同的特定作用和靶点，3）该菌群的作用似乎是由细菌衍生的小分子或生物活性成分介导的。这些发现有望为开发针对营养不足或过剩的治疗方法提供思路。本增刊的目的是总结我们的发现，特别针对肠道微生物组和无菌动物研究相关的技术和实验设计来讨论这项工作，最后为未来的研究提供一些考虑。
