Department of Physiology, Medical College, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, University of South China, Hengyang, 421001, Hunan, China.
Department of Physiology, School of Medicine, Hunan Normal University, Changsha, 410081, Hunan, China.
J Transl Med. 2024 Jan 23;22(1):97. doi: 10.1186/s12967-023-04629-y.
Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis remains largely incurable. In this review, we discuss emerging single-cell sequencing techniques and their novel insights into atherosclerosis. We provide examples of single-cell profiling studies that reveal phenotypic characteristics of atherosclerosis plaques, blood, liver, and the intestinal tract. Additionally, we highlight the potential clinical applications of single-cell analysis and propose that combining this approach with other techniques can facilitate early diagnosis and treatment, leading to more accurate medical interventions.
动脉粥样硬化是一种发生在动脉壁的慢性、进行性、炎症性疾病。尽管最近在提高疗效和延长生存时间的治疗方面取得了进展，但动脉粥样硬化仍然基本上无法治愈。在这篇综述中，我们讨论了新兴的单细胞测序技术及其在动脉粥样硬化研究中的新见解。我们提供了单细胞分析研究的例子，这些研究揭示了动脉粥样硬化斑块、血液、肝脏和肠道的表型特征。此外，我们还强调了单细胞分析的潜在临床应用，并提出将这种方法与其他技术相结合可以促进早期诊断和治疗，从而实现更准确的医疗干预。
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