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The failure of morphine to attenuate spinal cord nociceptive transmission through supraspinal actions in the cat.

作者信息

Sinclair J G

出版信息

Gen Pharmacol. 1986;17(3):351-4. doi: 10.1016/0306-3623(86)90053-4.

DOI:10.1016/0306-3623(86)90053-4
PMID:3013718
Abstract

Morphine sulphate was perfused between the third ventricle and cisterna magna in alpha-chloralose anaesthetized cats while recording from multireceptive dorsal horn neurones activated by peripheral noxious radiant heat. Morphine concentrations of 10(-5) and 10(-4) M were without effect, while 10(-3) M resulted in an increase in the spinal cord neuronal responses. The results do not support the notion that morphine activates a supraspinal mediated descending inhibition which antagonizes spinal cord nociceptive transmission.

摘要

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