新生儿败血症的降钙素原水平与抗生素使用时间。

Blood Procalcitonin Levels and Duration of Antibiotics in Neonatal Sepsis.

机构信息

Director Professor, Department of Neonatology, Maulana Azad Medical College, New Delhi, Delhi, India.

Senior Resident, Department of Neonatology, Maulana Azad Medical College, New Delhi, Delhi, India.

出版信息

J Trop Pediatr. 2019 Aug 1;65(4):315-320. doi: 10.1093/tropej/fmy053.

DOI:10.1093/tropej/fmy053

PMID:30137640

Abstract

OBJECTIVE

To determine the time to normalization of procalcitonin (PCT) levels and duration of antibiotics in neonatal sepsis.

METHODS

A prospective observational study design was used. The participants included were neonates with sepsis. The primary outcome measure was time to normalization of PCT levels and duration of antibiotics following clinical resolution.

RESULTS

Time to normalization of PCT levels was 9.6 ± 4.2 days in neonates with septic shock, 6.2 ± 2.5 days in neonates without shock, 9.6 ± 3.1 days in neonates with culture-positive sepsis and 6.4 ± 3.1 days in neonates with culture-negative sepsis. Time to normalization of PCT levels according to the stage of systemic inflammatory response syndrome was 5.8 ± 2.8 days in neonates with sepsis, 6.1 ± 3.1 days in those with sepsis syndrome, 6.3 ± 3.3 days in those with early septic shock and 9.4 ± 3.6 days in those with multiorgan dysfunction syndrome. There was no morbidity and mortality in any neonate in the 4-week follow-up.

CONCLUSION

The duration of antibiotics can be determined by observing the time to normalization of PCT following clinical resolution of sepsis.

摘要

目的

确定新生儿败血症降钙素原（PCT）水平正常化的时间和抗生素的持续时间。

方法

采用前瞻性观察研究设计。纳入的参与者为败血症新生儿。主要结局指标为临床缓解后 PCT 水平正常化的时间和抗生素的持续时间。

结果

在伴有休克的败血症新生儿中，PCT 水平正常化的时间为 9.6±4.2 天，在不伴有休克的败血症新生儿中为 6.2±2.5 天，在培养阳性败血症新生儿中为 9.6±3.1 天，在培养阴性败血症新生儿中为 6.4±3.1 天。根据全身炎症反应综合征的阶段，PCT 水平正常化的时间为败血症新生儿 5.8±2.8 天，败血症综合征新生儿 6.1±3.1 天，早期败血症休克新生儿 6.3±3.3 天，多器官功能障碍综合征新生儿 9.4±3.6 天。在 4 周的随访中，任何新生儿均无发病率和死亡率。