Department of Pediatrics, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, People's Republic of China.
Trishuli Hospital, Bidur, Nuwakot, Nepal.
JNMA J Nepal Med Assoc. 2022 Mar 11;60(247):318-324. doi: 10.31729/jnma.7324.
Neonatal sepsis is a serious condition in which the pathogens infiltrate the bloodstream, multiply and produce toxins causing deleterious effects to the health of neonates. It is divided into two types on the basis of the time of onset. Early onset sepsis occurs within 72 hours of birth and late onset sepsis begins after 72 hours of delivery. Neonatal sepsis continues to be a common and significant health care burden, especially in very low birth weight infants (with birthweight less than 1500 grams). Though intrapartum antibiotic prophylaxis has decreased the incidence of early-onset group B streptococcal infection dramatically, it still remains a major cause of neonatal sepsis. As the signs and symptoms of neonatal sepsis are nonspecific, early diagnosis and prompt treatment remain a challenge.
cytokines; immunoglobulin; neonatal sepsis; procalcitonin.
新生儿败血症是一种严重的疾病，病原体侵入血液，繁殖并产生毒素，对新生儿的健康造成有害影响。它根据发病时间分为两种类型。早发型败血症发生在出生后 72 小时内，晚发型败血症发生在出生后 72 小时后。新生儿败血症仍然是一个常见且严重的医疗负担，特别是在极低出生体重儿（出生体重小于 1500 克）中。尽管产时抗生素预防已显著降低了早发型 B 组链球菌感染的发生率，但它仍然是新生儿败血症的主要原因。由于新生儿败血症的体征和症状不具有特异性，早期诊断和及时治疗仍然是一个挑战。
细胞因子；免疫球蛋白；新生儿败血症；降钙素原。
