Dölken G, Bross K J, Hecht T, Brugger W, Löhr G W, Hirsch F W
Int J Cancer. 1986 Jul 15;38(1):55-9. doi: 10.1002/ijc.2910380110.
Antibody titers to Epstein-Barr virus (EBV)-associated early antigens (EA) and the viral capsid antigen (VCA) were determined by ELISA on 263 sera obtained from healthy donors, patients with Hodgkin's disease (HD), non-Hodgkin lymphomas (NHL), infectious mononucleosis (IM), Burkitt's lymphoma (BL), and nasopharyngeal carcinoma (NPC). As expected, most lymphoma patients showed markedly elevated anti-VCA IgG and anti-EA IgG antibody titers. Only one patient in the NHL group (n = 56) consisting of patients with lymphomas other than chronic lymphocytic leukemia (CLL) and hairy-cell leukemia (HCL), and 3 patients with HCL (n = 19) had high antibody titers of the IgA class to VCA and EA. Seventeen out of 48 patients (36%) with CLL had high IgA anti-VCA titers and 10 of these sera (21%) also contained IgA anti-EA. The geometric mean titer (GMT) of IgA anti-VCA was 2,510, the GMT of IgA anti-EA was 780. These antibody titers were about 10 times lower than the corresponding GMT of the NPC patients investigated in this study. The elevated IgG and IgA antibody titers to VCA and EA in CLL and HCL patients seem to reflect an immunodeficiency secondary to the malignant disease leading to reactivation of latent EBV infection. The possibility that at least some of these B-cell lymphomas are associated with EBV cannot be excluded.
通过酶联免疫吸附测定法（ELISA），对从健康供体、霍奇金淋巴瘤（HD）患者、非霍奇金淋巴瘤（NHL）患者、传染性单核细胞增多症（IM）患者、伯基特淋巴瘤（BL）患者和鼻咽癌（NPC）患者获取的263份血清，测定了针对爱泼斯坦-巴尔病毒（EBV）相关早期抗原（EA）和病毒衣壳抗原（VCA）的抗体滴度。正如预期的那样，大多数淋巴瘤患者显示抗VCA IgG和抗EA IgG抗体滴度显著升高。在由慢性淋巴细胞白血病（CLL）和毛细胞白血病（HCL）以外的淋巴瘤患者组成的NHL组（n = 56）中，只有1名患者，以及19名HCL患者中的3名，具有针对VCA和EA的IgA类高抗体滴度。48名CLL患者中有17名（36%）具有高IgA抗VCA滴度，其中10份血清（21%）也含有IgA抗EA。IgA抗VCA的几何平均滴度（GMT）为2510，IgA抗EA的GMT为780。这些抗体滴度比本研究中调查的NPC患者的相应GMT低约10倍。CLL和HCL患者中针对VCA和EA的IgG和IgA抗体滴度升高似乎反映了恶性疾病继发的免疫缺陷，导致潜伏性EBV感染的重新激活。不能排除至少部分这些B细胞淋巴瘤与EBV相关的可能性。
