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8.7兆电子伏特质子和23.5兆电子伏特氦-3离子在人淋巴细胞中诱导产生的染色体畸变

Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions.

作者信息

Edwards A A, Lloyd D C, Prosser J S, Finnon P, Moquet J E

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jul;50(1):137-45. doi: 10.1080/09553008614550511.

DOI:10.1080/09553008614550511
PMID:3013793
Abstract

This paper describes the irradiation of thin samples of blood with 8.7 MeV protons and 23.5 MeV helium-3 ions in the track segment mode. Chromosome aberrations in human lymphocytes have been scored. The relationship between dicentric yield and dose in Gy was Y = 0.044 D + 0.058 D2 for protons and Y = 0.394 D for helium ions. These results are compared with data from other laboratories using protons and an attempt is made to reconcile differences. An unexpected observation was that the ratio of the linear coefficients for helium ions and protons was about 9 whereas the ratio of the l.e.t. values was 4.5. This disagrees with current theory which predicts that the linear coefficients should be proportional to l.e.t. Possible sources of error in our experiments are discussed but do not adequately account for the discrepancies.

摘要

本文描述了在径迹段模式下用8.7兆电子伏质子和23.5兆电子伏氦-3离子对血液薄样品进行辐照的情况。对人类淋巴细胞中的染色体畸变进行了计分。质子的双着丝粒产额与戈瑞剂量之间的关系为Y = 0.044D + 0.058D²,氦离子的关系为Y = 0.394D。将这些结果与其他实验室使用质子的数据进行了比较,并试图调和差异。一个意外的观察结果是,氦离子与质子的线性系数之比约为9,而传能线密度值之比为4.5。这与当前理论不一致,该理论预测线性系数应与传能线密度成正比。讨论了我们实验中可能的误差来源,但不足以解释这些差异。

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