Takatsuji T, Takekoshi H, Sasaki M S
Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Dec;44(6):553-62. doi: 10.1080/09553008314551621.
The dose-response relationship and distribution of chromosome aberrations between cells was studied in G0 human peripheral blood lymphocytes following in vitro exposure to 4.9 MeV protons. The dose-response relationship of dicentric yield showed a significant dose-quadratic component and was best expressed by 2.76 X 10(-1) D + 1.36 X 10(-1) D2 (D in Gy). The distribution of dicentrics between cells was over-dispersed compared with a Poisson distribution. Analysis of the data indicated that the over-dispersion was caused by a spatial limitation in the interaction between tracks. The interaction distance was estimated to be around 0.2 microns.
研究了体外暴露于4.9 MeV质子后G0期人外周血淋巴细胞中细胞间染色体畸变的剂量反应关系和分布情况。双着丝粒产率的剂量反应关系显示出显著的剂量平方成分，最佳表达式为2.76×10(-1)D + 1.36×10(-1)D2（D以戈瑞为单位）。与泊松分布相比，细胞间双着丝粒的分布过度分散。数据分析表明，这种过度分散是由径迹间相互作用的空间限制引起的。相互作用距离估计约为0.2微米。
