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Use of DNA probes from the 5' flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus.

作者信息

Steere K, Sidwell B, Leach R, Ward F E, Taurog J D, Orr H T

出版信息

Hum Immunol. 1986 Jun;16(2):137-47. doi: 10.1016/0198-8859(86)90042-x.

DOI:10.1016/0198-8859(86)90042-x
PMID:3013813
Abstract

Two DNA probes isolated from the region 5' to the HLA-B gene are described. One of these, pCH6, detects a TaqI polymorphism which is correlated with serological alleles of HLA-B. Both probes are used to show a high level of DNA sequence homology between the 5' flanking region of HLA-B and HLA-C.

摘要

相似文献

1
Use of DNA probes from the 5' flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus.
Hum Immunol. 1986 Jun;16(2):137-47. doi: 10.1016/0198-8859(86)90042-x.
2
[TaqI restriction polymorphism and the HLA-B27 allele in ankylosing spondylitis].[强直性脊柱炎中的TaqI限制性片段长度多态性与HLA - B27等位基因]
Rev Rhum Mal Osteoartic. 1987 Mar;54(3):175-8.
3
HLA-B locus polymorphism: studies with a specific hybridization probe.HLA - B 基因座多态性：使用特异性杂交探针的研究
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Molecular analysis of HLA class I and class II antigen loss mutants reveals a homozygous deletion of the DR, DQ, and part of the DP region: implications for class II gene order.HLA I类和II类抗原缺失突变体的分子分析揭示了DR、DQ和部分DP区域的纯合缺失：对II类基因顺序的影响。
Hum Immunol. 1986 Jun;16(2):205-19. doi: 10.1016/0198-8859(86)90049-2.
5
The chromosome region containing the highly polymorphic HLA class I genes displays limited large scale variability in the human population.包含高度多态性的HLA I类基因的染色体区域在人类群体中表现出有限的大规模变异性。
EMBO J. 1988 Feb;7(2):395-400. doi: 10.1002/j.1460-2075.1988.tb02826.x.
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Association of four HLA class III region genomic markers with HLA haplotypes.四种HLA III类区域基因组标记与HLA单倍型的关联。
Tissue Antigens. 1991 May;37(5):191-6. doi: 10.1111/j.1399-0039.1991.tb01871.x.
7
Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series.通过对HLA - A、- B和 - C等位基因系列特有的结构标记进行表征，确定了HLA - B27 cDNA的完整序列。
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1428-32. doi: 10.1073/pnas.83.5.1428.
8
[Cross-reacting HLA-B alleles as genetic markers of HLA-B27 negative ankylosing spondylitis].[交叉反应性HLA - B等位基因作为HLA - B27阴性强直性脊柱炎的遗传标记]
Z Rheumatol. 1986 Sep-Oct;45(5):260-2.
9
Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism.
Hum Immunol. 1992 Mar;33(3):174-84. doi: 10.1016/0198-8859(92)90069-y.
10
Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes.HLA I类基因序列的比较。针对HLA - A、HLA - B和HLA - C基因的位点特异性寡核苷酸探针的推导。
J Biol Chem. 1985 Nov 5;260(25):13414-23.

引用本文的文献

1
Spinocerebellar ataxia: localization of an autosomal dominant locus between two markers on human chromosome 6.
Am J Hum Genet. 1987 Oct;41(4):524-31.
2
Localization of nucleotide sequence which determines Mongoloid subtype of HLA-B13.决定HLA - B13蒙古人种亚型的核苷酸序列的定位
Immunogenetics. 1989;29(2):117-20. doi: 10.1007/BF00395860.
3
Restriction fragment length polymorphism at the HLA-C locus.HLA - C基因座的限制性片段长度多态性
Immunogenetics. 1987;25(3):179-83. doi: 10.1007/BF00344032.
4
In vitro mutagenesis of HLA-B27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes.HLA - B27的体外诱变。α1结构域中一个未配对半胱氨酸残基的取代导致抗体定义表位的丧失。
J Clin Invest. 1988 Sep;82(3):987-92. doi: 10.1172/JCI113708.