Cheng Mengxia, Chen Zilin
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University, School of Pharmaceutical Sciences, Wuhan 430071, China.
J Pharm Anal. 2018 Aug;8(4):226-233. doi: 10.1016/j.jpha.2018.05.002. Epub 2018 May 11.
Capillary electrophoresis with many advantages plays an important role in pharmaceutical analysis and drug screening. This review gives an overview on the recent advances in the developments and applications of capillary electrophoresis in the field of enzyme inhibitor screening. The period covers 2013 to 2017. Both the pre-capillary enzyme assays and in-capillary enzyme assays which include electrophoretically mediated microanalysis (EMMA) and immobilized enzyme microreactor (IMER) are summarized in this article.
具有诸多优势的毛细管电泳在药物分析和药物筛选中发挥着重要作用。本文综述了毛细管电泳在酶抑制剂筛选领域的发展与应用的最新进展。时间跨度为2013年至2017年。本文总结了毛细管前酶分析以及毛细管内酶分析，其中毛细管内酶分析包括电泳介导微分析（EMMA）和固定化酶微反应器（IMER）。
